Today I investigated an issue that only appeared for one user on one specific computer in a domain. In this organization, local user profiles don't contain any important information - all work is done on a centralized database. It would have been possible to hunt the problem down, but finding the specific Registry entry would have taken quite a while. So I simply deleted the affected user's local profile using the User Profiles section of the Advanced tab on the System Properties window. When the user next logged on, they received a fresh profile unaffected by the glitch.
(I did later find what caused the problem, but was not able to narrow it down to the Registry entry that got the problematic application stuck.)
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